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These studies have highlighted the periconceptual period as a volatile spatiotemporal window in epigenomic development with additional support for this coming from animal models [118] discount norvasc 10 mg free shipping. Manipulation of dietary vitamin B and methionine during this periconceptual period in sheep led to heavier, fatter, and insulin-resistant animals [119]. In a large population-based obesity study, the maternal impact on this trait was shown to be greater [120], possibly due to maternally imprinted genes. As these imprinted loci are strongly interconnected with resource allocation, energy balance, and feeding behavior, early envir- onmental effects may have long-reaching consequences.

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